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21.
Production of submicron-size monodisperse polymer particles having aldehyde groups by seeded aldol condensation polymerization 总被引:2,自引:0,他引:2
Submicron-size monodisperse polystyrene/polyglutaraldehyde composite particles having aldehyde groups at the surfaces were produced by seeded aldol condensation polymerization of glutaraldehyde in the presence of polystyrene particles prepared by emulsifier-free emulsion polymerization. This technique is expected to be useful for the production of size-controlled polymer particles having aldehyde groups.Part CXXXVI of the series Studies on Suspension and Emulsion 相似文献
22.
Treatment of l(14S)-β-canadine methochloride (1b) and d(14R)-β-canadine methochloride (1c) with organometals gave d- (2b) and l-2,3-methylenedioxy-9,10-dimethoxyochotensanes (2c), respectively. The structures of these derivatives were proved by chemical and spectral means. The CD spectra of 2b showed Davydov split extrema centered at 284 nm with a positive first Cotton effect, while 2c showed the antipodal curve of 2b. Consequently, the absolute configurations of 2b and 2c were concluded the 14R and 14S, respectively.Application of the anionic rearrangement to N-methyltharictricavine chloride (15) led to 2,3 - methylenedioxy - 9,10 - dimethoxy - 13 - methylochotensane (18) together with the Hofmann methines 16 and 17. The stereochemistry of 18 was confirmed in terms of the nuclear Overhauser effects. 相似文献
23.
Kinetics of chemiluminescence reactions of 2-methyl-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one (1c, Cypridina luciferin analogue) and substituent effects of the 6-aryl group of derivatives 1 strongly suggest that the rate-determining step is a single electron transfer from an anion derived from 1 to a triplet molecular oxygen (O2) in the oxygenation process. 相似文献
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Fumoto M Hinou H Ohta T Ito T Yamada K Takimoto A Kondo H Shimizu H Inazu T Nakahara Y Nishimura S 《Journal of the American Chemical Society》2005,127(33):11804-11818
The chemoselective polymer blotting method allows for rapid and efficient synthesis of glycopeptides based on a "catch and release" strategy between solid-phase and water-soluble polymer supports. We have developed a heterobifunctional linker sensitive to glutamic acid specific protease (BLase). The general procedure consists of five steps, namely (i) the solid-phase synthesis of glycopeptide containing BLase sensitive linker, (ii) subsequent deprotections and the release of the glycopeptide from the resin, (iii) chemoselective blotting of the glycopeptide intermediates in the presence of water-soluble polymers with oxylamino functional groups, (iv) sugar elongations using glycosyltransferases, and (v) the release of target glycopeptides from the polymer platform by selective BLase promoted hydrolysis. The combined use of the solid-phase chemical syntheses of peptides and the enzymatic syntheses of carbohydrates on water-soluble polymers would greatly contribute to the production of complicated glycopeptide libraries, thereby enhancing applicative research. We report here a high-throughput synthetic system for the various types of MUC1 glycopeptides exhibiting a variety of sugar moieties. It is our belief that this concept will become part of the entrenched repertoire for the synthesis of biologically important glycopeptides on the basis of glycosyltransferase reactions in automated and combinatorial syntheses. 相似文献
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T Iwasaki H Yamazaki T Nishitani K Kondo T Sato 《Chemical & pharmaceutical bulletin》1992,40(1):122-126
A series of 2-aminoethanol derivatives was synthesized and their inhibitory activities against protein kinase C were investigated. Among these compounds, 2-endo-hexadecylamino-5-norbornene-2- exo-methanol (4h) and 2-endo-hexadecylamino-5-norbornene-2,3-exo-dimethanol (4i) inhibited protein kinase C at the IC50 values of 2 x 10(-5) and 1 x 10(-5) M, respectively, but not protein kinase A at a concentration of 1 x 10(-3) M. The structure-activity relationships are discussed. 相似文献